JOB REQUIREMENTS: Job Summary: The Department of Biomolecular Chemistry is a part of the School of Medicine and Public Health. Its research focuses on understanding the molecular underpinnings of biological processes, particularly as it relates to human disease. Research in the department spans a broad range of questions and methodologies, including DNA replication, chromatin structure, gene expression, protein and membrane trafficking, cell signaling and metabolism, cancer, embryogenesis, and pathogenesis. The department is housed within the Hector Deluca Biochemical Sciences complex, a state-of-the-art research and instructional complex located on Henry Mall, and has a reputation for carrying out federally funded, high level, competitive biomedical research. Visit https://bmolchem.wisc.edu/ to learn more. The Engin Laboratory within the Department of Biomolecular Chemistry (BMC) is focused on understanding how cellular stress response and organelle dysfunction plays a role in beta cell physiology and pathology. Current projects involve studying molecular mechanisms of cellular stress responses in pancreatic beta cells in autoimmune diabetes, ER-mitochondria communication, lysosome dysfunction, cellular senescence and the crosstalk between stressed beta cells and immune cells. The work involves working with the beta cell or immune cell-specific mouse models of the unfolded protein response pathway and mechanistic studies using cell culture (primary mouse and human islets), biochemical and immunological assays (Engin et al., Sci Transl Med 2013, Lee et al, Cell Metab 2020, Chen, et al., Nat Comm 2022). More information about our research and publications can be found at enginlab.org. The Research Scientist will play key roles in identifying research problems and developing research methodologies and procedures, implementing in vitro and in vivo experiments and training students. The Scientist will work on understanding the endoplasmic reticulum stress in beta cells of genetically engineered mouse and human islets. ER-mitochondria crosstalk and senescence will also be investigated in these models. Beta cell-immune cell communication and well as immune cell cellular stress... For full info follow application link. The University of Wisconsin-Madison is an Equal Opportunity and Affirmative Action Employer. Qualified applicants will receive consideration for employment without regard to, including but not limited to, race, color, religion, sex, sexual orientation, gender identity, national origin, age, pregnancy, disability, or status as a protected veteran and other bases as defined by federal regulations and UW System policies. We promote excellence through diversity and encourage all qualified individuals to apply. If you need to request an accommodation because of a disability, you can find information about how to make a request at the following website: https://employeedisabilities.wisc.edu/disability-accommodation-information-for-applicants/ ***** APPLICATION INSTRUCTIONS: Apply Online: ipc.us/t/2ADBE0EBBD8340F4