Minimum Requirements:Bachelor's degree in Neuroscience, Biomedical Sciences, Physiology or similar. Grade 3 (Hourly)Position Description:The Shin lab in the Department of Anatomical Sciences and Neurobiology at the University of Louisville KY, is accepting applications for a NIH-funded laboratory Research Assistant III. The successful candidate will join an enthusiastic and productive team aimed at investigating how neural circuits are altered in spinocerebellar ataxia type1 (SCA1) and identify brain areas for neuromodulation as a therapeutic strategy. SCA1 is a progressive, debilitating and fatally inherited neurodegenerative disease. The project will employ a SCA1 mouse model undergoing treadmill testing to assess changes in gait performance in a longitudinal study design. In vivo electrophysiological recordings are obtained to reveal how communication in various brain areas contribute to SCA1 motor symptomology with findings informing us on best practice to deliver deep brain stimulation to improve gait dysfunction. Lastly, immunocytochemistry of post-mortem tissue will unmask changes in brain morphology linked to SCA1 pathology and with therapeutic intervention. Overall, this position offers an exciting opportunity for a dedicated and highly motivated individual to contribute to groundbreaking research in neuroscience and contribute significantly to the scientific community. The successful candidate will have the chance to drive innovation and make meaningful contributions to the field.The candidate should also be highly motivated and able to work both independently and as part of a team. Surgical expertise (e.g., stereotaxic implants of recording/stimulating electrodes), behavior testing expertise, managing mouse colonies, genotyping and/or a background in ataxia, and electrophysiology are not required but would be beneficial.ResponsibilitiesAdminister the daily operations of the laboratory, ensuring compliance with safety protocols and regulatory standards.Mentor and supervise graduate, medical, undergraduate and/or high school students in their research projects, providing guidance and support.Train personnel in laboratory techniques, methodologies and safety procedures.Write IACUC proposals and ensure adherence to ethical guidelines in animal research.Perform genotyping and grow and maintain mouse colonies.Perform craniotomy surgeries in rodents to implant recording and stimulating electrodes.Conduct experiments employing and analyzing electrophysiological approaches to monitor neural activity from select brain regions.Optimize neuromodulation settings to improve SCA1 symptomology.Perform behavioral testing to measure gait, posture and locomotive performance.Assist with data analyses, grant writing and manuscript writing.Compensation will be commensurate to candidate experience.Equal Employment OpportunityThe University of Louisville is an equal opportunity, affirmative action employer, and is committed to providing employment opportunities to all qualified applicants without regard to race, sex, age, color, national origin, ethnicity, creed, religion, disability, genetic information, sexual orientation, gender, gender identity and expression, marital status, pregnancy, or veteran status. If you are unable to use our online application process due to an impairment or disability, please contact the Employment team at employment@louisville.edu or 502.852.6258.Assistance and AccommodationsComputers are available for application submission at the Human Resources Department located at 215 Central Avenue, Ste 205 - Louisville, Kentucky 40208.If you require assistance or accommodation with our online application process, please contact us by email at employment@louisville.edu or by phone 502-852-6258.