ROLE SUMMARY:

Are you a highly motivated scientist driven to expand your laboratory skills to make scientific breakthroughs? Investigative Toxicology is looking to grow its world class team of leading researchers in Drug Safety Research & Development in Groton, CT. Our mission is to design and carry out investigative studies to derisk toxicity findings for molecules in preclinical and clinical development. These efforts include delivering robust high quality investigative toxicology data to support portfolio progression and/or mechanistic understanding of anticipated or realized nonclinical toxicology findings.

We are seeking a highly skilled senior scientist (advanced degree is a plus) with a strong track record of scientific publications with demonstrated experience in the rapidly evolving area of in vitro New Approach Methodologies (NAMs), with focus on complex in vitro models (i.e., spheroids, organoids and microphysiological systems [MPS]/organ-chips). The successful candidate will develop and implement our scientific strategy for applying in vitro NAMs to nonclinical toxicology, including platform characterization and qualification, establishing an understanding of the strengths and limitations of various models, developing roadmaps for applying in vitro NAMs to high attrition organ toxicities, and guiding the interfaces with external consortia and peer industry groups. The individual in this role will participate as an individual contributor by applying their hands-on expertise to solve scientific problems within a matrixed laboratory environment. The successful candidate will have a deep knowledge of complex in vitro models with hands-on experience for applying these models to answer relevant scientific questions.

ROLE RESPONSIBIILTIES:

• Demonstrates scientific expertise in complex in vitro cell culture of spheroids, organoids, and iPSC-derived/primary cell models and/or organ-chips.

• Provides hands-on technical expertise in specific areas such as safety screening and mechanistic target organ in vitro assays in the Global Discovery, Investigative & Translational Sciences (GDITS) organization.

• Generates hypotheses and supporting high-quality data to enable portfolio progression and/or provide mechanistic understanding of nonclinical toxicology findings.

• Develops novel in vitro NAMs that will be used to address toxicity findings and/or screen subsequent molecules to improve the safety profile of new therapeutics.

• Executes analysis of internal and external data in support of in vitro-in vivo or nonclinical-clinical translation.

• Performs scientific evaluation of new technologies, assays and advancements that will enhance in vitro safety assessment to enable robust portfolio decisions.

• Effectively communicates and collaborates with Pfizer colleagues and global peers in DSRD, research units and partner lines, including the preparation of laboratory reports and presentations.

• Works together with Investigative Toxicology Lead and Investigative Toxicology Senior Lab Scientists to mentor and train junior lab colleagues.

• Performs all regulatory responsibilities in compliance with applicable regulatory standards.

QUALIFICATIONS:

• PhD degree in Toxicology, Molecular Biology, Pathobiology, Physiology, or related scientific field with 0-3 years of relevant experience; Candidates with bachelor's or master's degrees and 7+ years of experience in 2D/3D spheroid and organoid/MPS models with relevant examples of external publications and presentations will be considered.

• Deep knowledge of standard investigative toxicology laboratory capabilities, including biochemical, genomics, proteomic, flow cytometry, high-content imaging, targeted gene knockdown techniques and primary cell isolation and culture is strongly desired.

• Self-motivated, detail-oriented with excellent oral and written communication skills to effectively communicate within a team environment, enabling presentation and publication of scientific data and results.

• Strong interpersonal skills, able to take the initiative to lead projects and develop and execute a pre-determined plan.

• Needs to possess the ability to multi-task and align priorities with program objectives.

• Able to work in a fast-paced, rapidly changing environment, with solid decision-making skills to effectively troubleshoot and resolve highly complex technical and scientific problems.

Relocation support available

Work Location Assignment:On Premise

The annual base salary for this position ranges from $88,300.00 to $147,100.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.

Relocation assistance may be available based on business needs and/or eligibility.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

Research and Development