Kelly Science is seeking a Principal Scientist for a client located in Syracuse, NY.

Salary: $100,000-140,000/year depending on experience

Employment Type: Full Time; Direct Hire

Summary:

As the Principal Scientist, you will be working within the Antibody Drug Conjugate (ADC) and Purification Development team leading process development and production of antibody drug conjugates and providing on-floor GMP support of manufacturing. You will also be supporting development of the facility and laboratory design, build out, start-up, and technical process transfer of the ADC process from laboratory to manufacturing for ADC’s and other large molecule bioconjugates for several therapeutic areas.

Job Duties Include:

• Driving the CMC elements in relation to bioconjugation throughout the product life cycle using technical expertise in conjugation chemistry and downstream unit operations including tangential flow filtration, dead-end filtration, and protein chromatography.

• Leading the design and execution of laboratory experiments in the development, optimization, and characterization of antibody drug conjugates.

• Leading development, execution, and technology transfer of purification and bioconjugation processes.

• Developing, optimizing, and leading characterization of purification processes for antibodies and novel bioconjugation methodologies to improve antibody drug conjugates including High Throughput Screening methods for purification development.

• Bringing biologics from Phase I through commercialization including late-stage activities such as CMC risk assessments, process characterization, and process validation.

• Providing technical experience for on-floor support for production of GMP antibody and ADC batches.

Qualifications:

• PhD in Biology, Chemistry, Biochemistry, chemical engineering or a related field with 4-6 years of relevant experience with antibody drug conjugates and protein purification preferred. Master’s or bachelor’s degree Biology, Chemistry, Biochemistry, chemical engineering or a related field with 6-9 years of relevant experience in antibody drug conjugates and protein purification required.

• Hands on experience and knowledge of protein purification and characterization utilizing centrifugation, chromatography, normal-flow filtration, and tangential flow filtration required.

• Must have experience with technology transfers.

• Hands on experience and knowledge of analytical techniques such as Hydrophobic interaction Chromatography (HIC)-HPLC, Size Exclusion Chromatography (SEC), Liquid chromatography–mass spectrometry (LC-MS), Ion-Exchange (IEX), Reversed Phase (RP)-HPLC, routine DNA/RNA techniques, protein expression and purification, sodium dodecyl sulfate polyacrylamide gel electrophoresis, ultraviolet-visible spectrophotometry, and high-performance liquid chromatography.

• Strong communication skills and ability to explain complex scientific concepts to individuals with a non-science background.

As part of our promise to talent, Kelly supports those who work with us through a variety of benefits, perks, and work-related resources. Kelly offers eligible employees voluntary benefit plans including medical, dental, vision, telemedicine, term life, whole life, accident insurance, critical illness, a legal plan, and short-term disability. As a Kelly employee, you will have access to a retirement savings plan, service bonus and holiday pay plans (earn up to eight paid holidays per benefit year), and a transit spending account. In addition, employees are entitled to earn paid sick leave under the applicable state or local plan. Click here (https://www.mykelly.com/help-support-working-with-kelly-us/#Benefits) for more information on benefits and perks that may be available to you as a member of the Kelly Talent Community.

Why Kelly ® Science & Clinical?

Kelly Science & Clinical is your connection to premier scientific and clinical companies looking to hire industry experts just like you. Our team creates expert talent solutions to solve the world’s most critical challenges. Every day, we match science professionals with dream jobs that fit their skills, interests, and career goals—it’s the way we think job searching should be. Nearly 100 percent of our science recruiters have a professional background and education in science, so we know a thing or two about the science market and how to get your expertise noticed.

About Kelly

Work changes everything. And at Kelly, we’re obsessed with where it can take you. To us, it’s about more than simply accepting your next job opportunity. It’s the fuel that powers every next step of your life. It’s the ripple effect that changes and improves everything for your family, your community, and the world. Which is why, here at Kelly, we are dedicated to providing you with limitless opportunities to enrich your life—just ask the 300,000 people we employ each year.

Kelly Services is proud to be an Equal Employment Opportunity and Affirmative Action employer. We welcome, value, and embrace diversity at all levels and are committed to building a team that is inclusive of a variety of backgrounds, communities, perspectives, and abilities. At Kelly, we believe that the more inclusive we are, the better services we can provide. Requests for accommodation related to our application process can be directed to Kelly’s Human Resource Knowledge Center. Kelly complies with the requirements of California’s state and local Fair Chance laws. A conviction does not automatically bar individuals from employment. Kelly participates in E-Verify and will provide the federal government with your Form I-9 information to confirm that you are authorized to work in the U.S.

Kelly Services is proud to be an Equal Employment Opportunity and Affirmative Action employer. We welcome, value, and embrace diversity at all levels and are committed to building a team that is inclusive of a variety of backgrounds, communities, perspectives, and abilities. At Kelly, we believe that the more inclusive we are, the better services we can provide. Requests for accommodation related to our application process can be directed to Kelly’s Human Resource Knowledge Center. Kelly complies with the requirements of California’s state and local Fair Chance laws. A conviction does not automatically bar individuals from employment.