Reference #: 403444 Site Name: USA - Pennsylvania - Upper Providence Posted Date: Aug 27 2024

This is an opportunity for a Chemical Biologist/Cell Biologist who has a passion for identifying and validating targets from disease-relevant phenotypic screens.

You will collaborate with experts across multiple disciplines including genomic sciences, computational chemistry, biology, and medicinal chemistry. Additionally, there will be onward training in chemical biology available to you to develop your skills and progress.

We require this role to be based in Upper Providence only.

GSK's Chemical Biology department supports the delivery of our early-stage pipeline of innovative medicines which is built on GSK's strategic investment in human genetics and functional genomics.

Working in partnership with GSK's Research Units, our team of chemical biologists is accountable for the validation of novel targets identified from disease-relevant screens. Validation of these targets requires the design, development, and application of chemical biology assays and study of chemical or biological tools in mechanism of action studies. The department is increasingly interdisciplinary, integrating technical expertise in synthetic and medicinal chemistry, molecular and cell biology, and pharmacology. To deliver on our growing portfolio, we are expanding to add technical capabilities which will aid the discovery of tractable targets and guide optimal choice of modality.

Key Responsibilities and Skills Include: Development of target relevant, fit for purpose chemical biology assays for target identification (Micromapping, photoaffinity labeling, proximity labeling, TurboID) and target engagement (CETSA, NanoBRET, HTRF) Understanding and appreciation of cell and molecular biology techniques which can be used to characterize chemical tools for drug target identification and validation Apply a deep understanding of cellular pharmacology to solve complex biological problems, including quantification of tool potency, efficacy, and specificity in relevant assay systems Experience with cellular and biochemical assay formats in low to medium throughput formats is highly desired, familiarity with drug discovery is a plus Comprehensive understanding of diverse drug modalities, which includes but is not limited to, the knowledge and application of antibody-drug conjugates (ADCs), PROTACs, molecular glues and oligonucleotides Influence experimental strategy of the team and contribute to a culture and environment of scientific excellence Capable of working both independently and collaboratively in an open lab setting as required Why you?Basic Qualifications: We are looking for professionals with these required skills to achieve our goals:

B.Sc in chemical biology, cell biology or pharmacology or related fields. 3+ Yrs of Industry experience. Experiences working in integrated, multidisciplinary teams of e.g. chemists, cell biologists, biochemists, chemoproteomics scientists and computational biologists. Experience with Microsoft Word, Excel, Powerpoint, PRISM, data analysis software, etc

Preferred Qualifications: If you have the following characteristics, it would be a plus: M.S degree with post-degree experience in chemical biology, cell biology or pharmacology or related fields Strong problem-solving skills and ability to adapt quickly Strict attention to detail and excellent communication (oral and written) skills Document completed lab work and results promptly, clearly, and accurately

#LI-GSK

Please visit  GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK? Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, mor sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).

Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.

GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.