We are seeking a COMPUTATIONAL BIOLOGIST who will join the team of Dr. Mariella Filbin in the Department of Pediatric Oncology at the Dana-Farber Cancer Institute. We aim to develop new therapeutic approaches for children’s brain tumors by overcoming “differentiation blocks” in cancer cells. Specifically, our research focuses on understanding the genetic and epigenetic changes that lock cancer cells in a stem-like state, preventing differentiation into normal cells.

The successful candidate will collaborate closely with other scientists across the Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life-changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS, and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds and design programs to promote public health, particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physicians/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

• Assess and integrate new methods and algorithms for single-cell multi-omics sequencing data processing and analysis.

• Evaluate other experimental data generated in our labs (e.g., CRISPR screens, drug synergy experiments) by adapting existing pipelines and algorithms.

• Characterize chromatin states and transcriptional states of cells during normal development and oncogenesis, for example, from RNA-seq, ATAC-seq, and ChIP-seq data.

• Summarize and report data and analytical methods in oral and written format.

• Publish scientific papers in high-impact journals and present findings at seminars and conferences.

Minimum Education:

Bachelor's degree required in a STEM field. Master’s degree preferred in bioinformatics, computational biology, statistics, biostatistics, computer science and/or the life sciences.

Minimum Education:

1 year with Bachelor’s degree or 0 years with Master’s degree; academic research experience or authorship in scientific publications experience may substitute for work experience.

• Programming experience with at least one high-performance statistical computing software (e.g. R, Python).

• Familiarity with Linux/Unix in a cluster-computing environment is required.

• Demonstrated experience in processing data from large-scale genomic and genetic platforms, such as transcriptomic, epigenetic, proteomic, or Next Generation Sequencing data, including the understanding of pathway/network analyses and gene regulation.

• Solid understanding of statistical methods relevant to large-scale analysis of biological data sets

• Experience designing, analyzing, and interpreting single-cell multiomics experiments, including single-cell RNA-seq, single-cell ATAC-seq, and single-cell methylation profiling, is a significant plus.

• Knowledge of and experience with common bioinformatics databases, resources, and tools.

• Knowledge of fundamental concepts in biology and statistics. Experience in oncology or immunology research is desirable.

• Able to communicate and collaborate effectively with scientists across a broad range of disciplines.

• Organizational solid techniques, including the ability to handle a variety of tasks in a fast-paced environment.

• Demonstrated interpersonal skills, including experience collaborating with a diverse interdisciplinary research team.

The ideal candidate will be passionate about advancing scientific discovery, a team player, and highly self-motivated. A minimum of two years of availability is needed.

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.

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